Free and nanoencapsulated curcumin prevents scopolamine-induced cognitive impairment in adult zebrafish

Cognitive dysfunctions are the main symptoms associated with Alzheimer's disease (AD). In last decade, use of natural substances to prevent or alleviate neurological have attracted great interest. Curcumin, polyphenolic component turmeric ( Curcuma longa ) rhizomes, has a variety beneficial properties, including potent antioxidant and anti-inflammatory properties. Despite therapeutic potential for neurodegenerative diseases AD, this compound as drug in therapies huge limitations due its low water solubility, physicochemical instability, poor bioavailability. Nanotechnology is an important tool overcome these drawbacks. Here, safety curcumin nanoencapsulated form was evaluated using zebrafish embryos. We also investigated protective effect (50 mg/kg, single injection, i.p.) against scopolamine-induced memory deficits adult zebrafish. The embryotoxicity test revealed that formulations any dose tested did not cause embryo mortality affect hatching rate. Data showed both effective preventing cognitive impairments without altering animals' locomotion. These findings suggest treatments safe could be useful enhancing function AD other age-related disorders. • Curcumin do mortality. None compounds affected general locomotor activity. Both